When these substances gather together, this causes the symptoms of kidney disease, which can include high blood pressure, excessive tiredness, fluid retention and possibly lower back pain. When the kidneys are not working correctly, waste products and excess fluid can build up and the levels of sodium, potassium, phosphate and calcium are not regulated correctly. In addition to making hormones, the kidneys also respond to a number of hormones including vitamin D, aldosterone, prostaglandins, cortisol, parathyroid hormone and calcitonin. Renin is an enzyme, also produced by the kidneys, that plays an important role in the renin– angiotensin– aldosterone hormonal system, which helps to control blood pressure. The substances are one way in which the production of renin is stimulated. The kidneys also produce prostaglandins, hormone-like substances, made from lipid ( fat). It acts in bone marrow to stimulate the production of mature red blood cells, to maintain healthy oxygen levels in our tissues. Active vitamin D stimulates the uptake of calcium from food, is important for the maintenance of healthy bones and also helps to regulate the response of the immune system to infection.Įrythropoietin is produced when oxygen levels in the blood are low. Vitamin D is essential for a number of different functions in the body. Most of the vitamin D that is in the blood is inactive and it is modified by the kidney and other tissues to activate it. The kidneys make two main hormones, vitamin D and erythropoietin. As this fluid passes through the nephron, substances that the body wants to retain (such as sodium, potassium, proteins and most of the water) are re-absorbed back into the blood. The substances that need to be removed from the body, such as waste products including the remains of drugs and alcohol, are retained in the fluid and removed from the body in the form of urine. The kidneys filter around 200 litres of blood a day and produce between one to two litres of urine. They activate vitamin D, which helps to maintain strong bones, and produce erythropoietin, a hormone that is vital for the production of red blood cells.Įach kidney contains 1.0–1.5 million small tubes called nephrons. The kidneys filter blood through a network of small blood vessels called the glomerulus. This produces a solution that then flows through the nephrons. The kidneys ensure that the make-up and volume of the fluids in the body is correct. They help control the chemical balance of the blood and regulate the body's level of sodium, potassium and calcium. The kidneys remove waste products and excess water from the body and so help to regulate blood pressure.
They activate vitamin D, which helps to maintain strong bones.The kidneys remove waste products and excess water from the body and so help to regulate blood pressure.
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